Five-year-old Melissa Brannen went missing from a Christmas party in 1989. The fibers on her clothes were the only means for police to determine her abductor. Police grew suspicious of Cal Hughes who was washing his clothes at 1am when they came to his home. Will forensic tests of his clothing convict Hughes of abduction with intent to harm?

A Chemist suddenly starts to suffer from foot pain, partial numbness, and hair loss. He was initially mis-diagnosed. Investigators started searching the lab he worked in and interrogated some co-workers. Eventually, the chemist dies and forensic evidence leads investigators to who poisoned him.

A piece of rope holds the key to identifying a serial killer who has been preying on boys in Maine and Nebraska.

In 1978, Mark Fair returned home from work to find his fianc�e Karla Brown dead. The condition of Karla's body told investigators that she was a victim of sexual assault.The police questioned neighbors Paul Main and John Prante, but they were considered low-level suspects. During autopsy, they were able to re-examine bite marks found on her body. A computer enhancement gave a better view of the bite marks and the science of forensic odontology identified John Prante. Would Prante be tried and fo